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PGD (Pre-implantation Genetic Diagnosis)



PGD (Pre-implantation Genetic Diagnosis)

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It refers to genetic profiling of embryos prior to implantation (as a form of embryo profiling), and sometimes even of oocytes prior to fertilization. Here a genetic material from an Ovum or Embryo is taken and studied before embryo transfer. PGD can potentially be used

1. to select embryos to be without a genetic disorder

2. to have increased chances of successful pregnancy

3. to match a sibling in HLA type in order to be a donor

4. to have less cancer predisposition

5. Various Genetic diseases where it can be used are

Cystic Fibrosis, Beta-Thalassemia, Sickle Cell Disease and Spinal Muscular Atrophy (Type 1) Myotonic Mystrophy, Huntington's Disease and Charcot-Marie-Tooth Disease; Fragile X Syndrome, Haemophilia A and Duchenne Muscular Dystrophy.

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