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PGD (Pre-implantation Genetic Diagnosis)



PGD (Pre-implantation Genetic Diagnosis)

Assisted Reproduction Technologies (ART) 0

Ruby Hall Clinic under the expert guidance of Dr. Sunita Tandulwadkar now enables couples with infertility issues to test their embryos with PGD (Pre-implantation Genetic Diagnosis), so that they do not pass their genetic disorders on to their children. This is a highly advanced diagnostic technique for testing embryos for certain chromosomal or genetic abnormalities. Couples who are resorting to IVF (In Vitro Fertilization) can now test for unaffected embryos before they are transferred into uterine cavity and the woman gets pregnant.

Who Should Consider PGD?

Having a PGD done should be considered - • When either spouse has inherited or are carriers of certain genetic defect/s or has a family history of birth defects or chromosomal abnormality. • There is a conceived risk of the child inheriting a genetic disorder. • The woman with advanced age and especially when she is more than 35 years old. • The woman has suffered miscarriage repeatedly. • Repeated IVF failures. • Chromosomal abnormality has been detected in previous pregnancy/s

Steps Involved in PGD

PGD, as the name suggests is not mainly a technique for treating infertility, but rather a test to find out if the embryo is without inherited genetic defects, and fit enough to be implanted in the womb. Here are the usual steps involved in PGD.

Step 1 The couple undergoes In Vitro Fertilization procedure where the eggs are collected and fertilized.

Step 2 The embryo grows for a couple of days in the lab until division of cells take place, and there are about eight cells ( cleavage stage embryos).

Step 3 The expert embryologist will remove one or two blastomeres (cells) from the dividing embryo.

Step 4 These removed cells undergo tests to find out if they contain gene/s that can cause genetic disorder/s.

Step 5 Embryos that are not affected by genetic condition are transferred into the womb, which will result in pregnancy.

Step 6 Affected embryos are destroyed. Healthy, unaffected surplus embryos if remaining after transfer may be frozen for being used later.

Step 7 A couple of weeks after the transfer, the woman undergoes a pregnancy blood test.

Instead of testing from a three-day old embryo, certain embryologists might let the embryo develop for about six days, so that there are about 150 cells. Since more cells are available, more cells can be removed for getting accurate results, and the embryo's viability can remain unaffected as well.

What can PGD Reveal?

PGD testing can reveal many types of single gene disorders, and some of the main ones are - • Duchenne muscular dystrophy • Cystic fibrosis • Huntington's disease • Fragile X syndrome • Thalassaemia

Techniques Used for Genetic Analysis

PCR (Polymerase Chain Reaction) and FISH (Fluorescent In Situ Hybridization) are the two main techniques used in PGD for genetic analysis. FISH is mainly used for detecting abnormalities in chromosomes, while PCR is useful in diagnosing monogenic disorders. Apart from these two techniques, new testing procedures are being implemented for deriving results that are more accurate.

If you are being impregnated through IVF, it is a good idea to do PGD (Pre-implantation Genetic Diagnosis) test. Ruby Hall Clinic uses the latest equipments and testing methods for highly accurate results. Couples can consult Dr. Sunita Tandulwadkar, who is highly experienced in PGD testing and has gained international recognition in treating infertility.

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Maharashtra, India
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